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‘Nuclear’ oncogenes convert extracellular stimuli into changes in the genetic program

Authors
Journal
Trends in Genetics
0168-9525
Publisher
Elsevier
Publication Date
Volume
5
Identifiers
DOI: 10.1016/0168-9525(89)90041-3
Disciplines
  • Biology

Abstract

Abstract Recent discoveries have advanced our understanding of oncogene action: transcription factors are encoded by cellular (nuclear) oncogenes and the activity of transcription factors is modulated in response to extracellular stimuli. Moreover, the nuclear oncoproteins appear to represent the gene-proximal ends of a network of cellular oncoproteins that link extracellular stimuli to the transcriptional machinery and thus to the program of genes a cell will express.

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