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The international standards for interleukin-1α and interleukin-1β:Evaluation in an international collaborative study

Authors
Journal
Journal of Immunological Methods
0022-1759
Publisher
Elsevier
Publication Date
Volume
142
Issue
1
Identifiers
DOI: 10.1016/0022-1759(91)90286-o
Keywords
  • Interleukin-1
  • Collaborative Study

Abstract

Abstract Three ampouled preparations of interleukin-1α (IL-1α) and three ampouled preparations of interleukin-1β (IL-1β) were evaluated by 13 laboratories in six countries for their suitability to serve as international standards for these materials. The preparations were assayed in in vitro and in vivo bioassays, radioreceptor assays and immunoassays. On the basis of the results reported here, with the agreement of participants in the study and with the authorization of the Expert Committee on Biological Standardization (ECBS) of the World Health Organization (WHO), one of the preparations of IL-1α and one of the preparations of IL-1β were established as international standards for three materials. Further, since the relative activities of IL-1α and IL-1β were dependent upon the assay systems used, it was decided that reference should be made to units of IL-1α activity or IL-1β activity rather than to IL-1 activity.

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