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Health benefits of high-density lipoproteins in preventing cardiovascular diseases

Authors
Journal
Journal of Clinical Lipidology
1933-2874
Publisher
Elsevier
Volume
6
Issue
6
Identifiers
DOI: 10.1016/j.jacl.2012.04.004
Keywords
  • Atherogenesis
  • Cardiovascular Diseases
  • Cholesterol Efflux
  • Hdl
  • Paraoxonase 1
  • Reverse Cholesterol Transport
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Plasma levels of high-density lipoprotein (HDL) are strongly and inversely correlated with atherosclerotic cardiovascular diseases. However, it is becoming clear that a functional HDL is a more desirable target than simply increasing HDL-cholesterol levels. The best known antiatherogenic function of HDL particles relates to their ability to promote reverse cholesterol transport from peripheral cells. However, HDL also possesses antioxidant, anti-inflammatory, and antithrombotic effects. This review focuses on the state of knowledge regarding assays of HDL heterogeneity and function and their relationship to cardiovascular diseases.

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