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Displacement chromatography on cyclodextrin-silicas:II. Separation of cis-trans isomers in the reversed-phase mode on α-cyclodextrin-silica

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
484
Identifiers
DOI: 10.1016/s0021-9673(01)88972-x

Abstract

Abstract The feasibility of preparative separations of cis-trans isomers by displacement chromatography on analytical-scale α-cyclodextrin-silica columns operated in the reversed-phase mode is demonstrated by using the isomers of 3-hexen-1-ol as model substrates and n-alkanols as displacers. The importance of matching the size of the cyclodextrin cavity and the solutes is shown. The crucial role of the displacer (both type and concentration) in the success of the displacement chromatographic separation is demonstrated.

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