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Melatonin and clinical application

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  • [Sdv:Bdlr] Life Sciences/Reproductive Biology
  • [Sdv:Bdlr] Sciences Du Vivant/Biologie De La Reproduction
  • [Sdv:Aen] Life Sciences/Food And Nutrition
  • [Sdv:Aen] Sciences Du Vivant/Alimentation Et Nutrition
  • [Sdv:Bdd] Life Sciences/Development Biology
  • [Sdv:Bdd] Sciences Du Vivant/Biologie Du Développement
  • Medicine
  • Pharmacology


Review article Melatonin and clinical application Lennart Wetterberg Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (Received 25 March 1999; accepted 16 April 1999) Abstract - A review of the different publications dealing with melatonin in humans shows that this field has been very active in the last few years. Normative melatonin values have been defined. Various relationships between melatonin and other traits have been studied, such as sleep, circadian rhythm, surgical stress and anaesthesia. Age-related melatonin studies and melatonin during depres- sion and other psychiatric disorders have been reviewed. Finally, some studies have been performed to use melatonin as a medication for sleep disturbance in depression, for jet-lag and as a skin protector for ultraviolet light. © Inra/Elsevier, Paris melatonin / clinics / depression / sleep / circadian Résumé ― Mélatonine et applications cliniques. Une revue des différentes publications traitant de la mélatonine chez l’homme montre que ce champ a été très actif au cours de ces dernières années. Des normes de concentrations de mélatonine ont été définies. Diverses relations entre la mélatonine et d’autres caractéristiques comme le sommeil, les rythmes circadiens, le stress chirurgical et l’anes- thésie ont été étudiées. Des études sur la mélatonine au cours du vieillissement et sur la mélatonine pendant la dépression et au cours d’autres désordres psychiatriques ont été conduites. Enfin, plu- sieurs essais ont utilisé la mélatonine comme médicament pour traiter les troubles du sommeil pen- dant la dépression, pour atténuer le jet-lag et comme protecteur de la peau contre les UV. © Inra/ Elsevier, Paris mélatonine / clinique / dépression / sommeil / circadien 1. INTRODUCTION Over the last couple of years there has been a rapid development in studies about the pineal hormone melatonin in humans. The situation today is very different from two decades ago when only a few clinical resu

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