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Yellow fever in Central Uganda, 1964 Part III. Virus isolation from man and laboratory studies

Authors
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiene
0035-9203
Publisher
Oxford University Press
Publication Date
Volume
59
Issue
4
Identifiers
DOI: 10.1016/0035-9203(65)90064-7
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Yellow fever virus was isolated and re-isolated in mice from the serum and cerebral fluid of a patient who died in central Uganda in May 1964. Provisional identification was made within 48 hours of the first mice sickening, by the use of the haemagglutination-inhibition test. This was confirmed by a later reciprocal cross-neutralization test with the French neurotropic strain of yellow fever virus, and by the typical histological appearances of the liver of a rhesus monkey, destroyed when febrile after inoculation with infected mouse brains.

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