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Coping with unpredictability: Dopaminergic and neurotrophic responses to omission of expected reward in Atlantic salmon (Salmo salar L.).

Authors
Publisher
Public Library of Science
Publication Date
Keywords
  • Comparative Studies Are Imperative For Understanding The Evolution Of Adaptive Neurobiological Proce
  • Cognition
  • And Emotion
  • Previously We Have Reported That Prolonged Omission Of Expected Rewards (Oer
  • Or 'Frustrative Nonreward') Causes Increased Aggression In Atlantic Salmon (Salmo Salar)
  • Here We Report Changes In Brain Monoaminergic Activity And Relative Abundance Of Brain Derived Neuro
  • Groups Of Fish Were Initially Conditioned To Associate A Flashing Light With Feeding
  • Subsequently
  • The Expected Food Reward Was Delayed For 30 Minutes During Two Out Of Three Meals Per Day In The Oer
  • While The Previously Established Routine Was Maintained In Control Groups
  • After 8 Days There Was No Effect Of Oer On Baseline Brain Stem Serotonin (5-Ht) Or Dopamine (Da) Act
  • Subsequent Exposure To Acute Confinement Stress Led To Increased Plasma Cortisol And Elevated Turnov
  • The Da Response Was Potentiated And Da Receptor 1 (D1) Mrna Abundance Was Reduced In The Oer-Exposed
  • Indicating A Sensitization Of The Da System
  • In Addition Oer Suppressed Abundance Of Bdnf In The Telencephalon Of Non-Stressed Fish
  • Regardless Of Oer Treatment
  • A Strong Positive Correlation Between Bdnf And D1 Mrna Abundance Was Seen In Non-Stressed Fish
  • This Correlation Was Disrupted By Acute Stress
  • And Replaced By A Negative Correlation Between Bdnf Abundance And Plasma Cortisol Concentration
  • These Observations Indicate A Conserved Link Between Da
  • Neurotrophin Regulation
  • And Corticosteroid-Signaling Pathways
  • The Results Also Emphasize How Fish Models Can Be Important Tools In The Study Of Neural Plasticity

Abstract

Coping with unpredictability: Dopaminergic and neurotrophic responses to omission of expected reward in Atlantic salmon (Salmo salar L.). - DTU Orbit (16/05/14) Coping with unpredictability: Dopaminergic and neurotrophic responses to omission of expected reward in Atlantic salmon (Salmo salar L.). - DTU Orbit (16/05/14) Vindas, Marco A; Sørensen, Christina; Johansen, Ida; Folkedal, Ole; Höglund, Erik; Khan, Uniza W; Stien, Lars H; Kristiansen, Tore; Braastad, Bjarne O; Overli, Oyvind / Coping with unpredictability: Dopaminergic and neurotrophic responses to omission of expected reward in Atlantic salmon (Salmo salar L.).. In: PloS one., Vol. 9, No. 1, 2014, p. e85543. Publication: Research - peer-review › Journal article – Annual report year: 2014

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