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Transforming growth factor-beta (TGFβ) is chemotactic for human monocytes and induces their expression of angiogenic activity

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
157
Issue
2
Identifiers
DOI: 10.1016/s0006-291x(88)80319-x

Abstract

Summary TGF β stimulates human blood monocyte migration, with peak migratory response occurring consistently at a concentration of 16–100fg/ml. Checkerboard analysis revealed both chemotactic and chemokinetic components to this response. At higher concentrations (10–100pg/ml), TGF β stimulated expression of angiogenic activity by monocytes. While mRNA for TNF α was undetectable in resting monocytes, high steady state levels of TNF α mRNA were rapidy induced in TGF β-treated monocytes. TGF β is secreted by a number of neoplastic cells as well as normal cells such as platelets and lymphocytes. TGF β may recruit monocytes from the circulation, and subsequently activate them to express angiogenic activities such as TNF α, thus playing an important role in wound repair, inflammation and tumor growth.

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