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Fluoroalkyl substituted (Z)-dehydro α-amino ester as a building block for the fluorine-containing cyclopropyl α-amino esters and dihydrooxazole

Authors
Journal
Journal of Fluorine Chemistry
0022-1139
Publisher
Elsevier
Publication Date
Volume
129
Issue
6
Identifiers
DOI: 10.1016/j.jfluchem.2008.03.008
Keywords
  • Dehydro Amino Acids
  • Fluorine-Containing Building Blocks
  • Fluorine-Containing Cylcopropyl Amino Acids
  • Cycloadditions
  • Dihydrooxazoles
Disciplines
  • Biology

Abstract

Abstract Multi-functionalized β-trifluoromethyl and β-difluoromethyl substituted ( Z)-α,β-dehydro α-amino esters have been successfully prepared from N-protected fluorinated threonine ester. Applications of this new fluorine-containing building block to the synthesis of biologically important fluorinated cylcopropyl α-amino esters and dihydrooxazole ester have also been reported.

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