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Discovering the Targets of Drugs Via Computational Systems Biology*

Authors
Journal
Journal of Biological Chemistry
0021-9258
Publisher
American Society for Biochemistry and Molecular Biology
Publication Date
Volume
286
Issue
27
Identifiers
DOI: 10.1074/jbc.r110.174797
Keywords
  • Minireviews
Disciplines
  • Biology
  • Chemistry
  • Computer Science
  • Medicine
  • Pharmacology

Abstract

Computational systems biology is empowering the study of drug action. Studies on biological effects of chemical compounds have increased in scale and accessibility, allowing integration with other large-scale experimental data types. Here, we review computational approaches for elucidating the mechanisms of both intended and undesirable effects of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy.

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