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An Immunohistochemical Study of the Distribution of the Measles Virus Receptors, CD46 and SLAM, In Normal Human Tissues and Subacute Sclerosing Panencephalitis

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Keywords
  • We Have Compared The Expression Of The Known Measles Virus (Mv) Receptors
  • Membrane Cofactor Protein (Cd46) And The Signaling Lymphocyte-Activation Molecule (Slam)
  • Using Immunohistochemistry
  • In A Range Of Normal Peripheral Tissues (Known To Be Infected By Mv) As Well As In Normal And Subacu
  • To Increase Our Understanding Of How These Receptors Could Be Utilized By Wild-Type Or Vaccine Strai
  • The Results Have Been Considered With Regard To The Known Route Of Infection And Systemic Spread Of
  • Strong Staining For Cd46 Was Observed In Endothelial Cells Lining Blood Vessels And In Epithelial Ce
  • As Well As In Langerhans' And Squamous Cells In The Skin
  • In Lymphoid Tissues And Blood
  • Subsets Of Cells Were Positive For Slam
  • In Comparison To Cd46
  • Which Stained All Nucleated Cell Types
  • Strong Cd46 Staining Was Observed On Cerebral Endothelium Throughout The Brain And Also On Ependymal
  • Comparatively Weaker Cd46 Staining Was Observed On Subsets Of Neurons And Oligodendrocytes
  • In Sspe Brain Sections
  • The Areas Distant From Lesion Sites And Negative For Mv By Immunocytochemistry Showed The Same Distr
  • However
  • Cells In Lesions
  • Positive For Mv
  • Were Negative For Cd46
  • Normal Brain Showed No Staining For Slam
  • And In Sspe Brain Only Subsets Of Leukocytes In Inflammatory Infiltrates Were Positive
  • None Of The Cell Types Most Commonly Infected By Mv Show Detectable Expression Of Slam
  • Whereas Cd46 Is Much More Widely Expressed And Could Fulfill A Receptor Function For Some Wild-Type
  • In The Case Of Wild-Type Stains
  • Which Are Unable To Use Cd46
  • A Further As Yet Unknown Receptor(S) Would Be Necessary To Fully Explain The Pathology Of Mv Infecti
Disciplines
  • Musicology

Abstract

2013 - 2014 ...real solutions for communities ENGAGE Welcome to The SCIENCE SHOP Welcome to the third edition of the Science Shop ezine Engage. We hope that you enjoy reading about some of the community projects we have worked on with students during the past year. The Science Shop is a community research resource working with voluntary and community sector organisations right across Northern Ireland. We hope this information will help you think about your own research needs. Please contact us if you would like to discuss a project idea or would like more information about what we do. University of Ulster Science Shop ( 028 7167 5448 * [email protected] Queen’s University Belfast Science Shop ( 028 9097 3107 * [email protected] Music to their ears Sustainable NI are interested in how to work effectively with local groups to help them build sustainable communities. Students from the School of Geography at Queen’s worked with nine community groups across Northern Ireland piloting workshops examining issues such as water management, sustainable transport, energy management and waste issues. The students examined different methodologies for encouraging Twenty final year Ulster Music students took up the challenge to work with Science Shop community partners for their music in the community module. Rachel Houston and Michael Norton, worked in partnership with Foyle Downs Syndrome Trust, helping the group offer children music and singing classes after school. For eight weeks the students facilitated workshops that were thoroughly enjoyed by the Primary school participants, their siblings and parents. Rachel and Michael are pictured at Ulster Graduation in the Millennium Forum in July. Encouraging communities to make sustainable lifestyle choices local communities to consider reducing their impact on the environment. They concluded that different age groups responded differently to w

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