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An efficient protocol for copper- and amine-free Sonogashira reactions catalyzed by mononuclear palladacycle complexes containing bidentate phosphine ligands

Authors
Journal
Catalysis Communications
1566-7367
Publisher
Elsevier
Publication Date
Volume
37
Identifiers
DOI: 10.1016/j.catcom.2013.03.028
Keywords
  • Palladacycle Phosphine Complexes
  • Copper- And Amine-Free Sonogashira Cross-Coupling
  • Mild Reaction Condition
  • Efficient Protocol
  • 31P Nmr Spectroscopic Investigations

Abstract

Graphical abstract An efficient protocol copper- and amine-free palladium-catalyzed Sonogashira reaction of various aryl halides with phenylacetylene in mild reaction condition has been developed. Various aryl halides were coupled with phenylacetylene under air in the presence of 0.001mol% of the moisture-stable and homogeneous catalysts to afford corresponding C–C products in moderate to good yields. 31P NMR studies showed that palladacycle 1 can be reduced to zerovalent palladium in methanol, by forming dppe dioxide.

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