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Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
39
Issue
52
Identifiers
DOI: 10.1016/s0040-4039(98)02169-8

Abstract

Abstract Coupling of Fmoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried out in an organic medium. The necessity of using an inorganic base like NaHCO 3 Na 2CO 3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. The coupling is reasonably fast, clean, racemization free and high yielding.

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