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Normobaric CO2 and hyperbaric O2 stimulate the same neurons in the solitary complex

Respiratory Research
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/rr124
  • Oral Presentations - Session 6
  • Biology


com m entary review reports m eeting abstracts prim ary research S1 Available online Meeting abstracts Neural control of breathing An Official Satellite of the International Congress of Physiological Sciences (IUPS) 2001, Rotorua, New Zealand, 1–4 September 2001 Received: 2 August 2001 Published: 17 August 2001 Respir Res 2001, 2 (suppl 1):S1–S37 © 2001 BioMed Central Ltd (Print ISSN 1465-9921; Online ISSN 1465-993X) ORAL PRESENTATIONS — SESSION 1 Ontogeny and phylogeny of respiratory control 1.1 Early development of respiratory rhythm generation in mice and chicks J Champagnat, G Fortin, S Jungbluth, V Abadie, F Chatonnet, E Dominquez-del-Toro, L Guimarães UPR 2216 (Neurobiologie Génétique et Intégrative), IFR 2118 (Institut de Neurobiologie Alfred Fessard), CNRS, 91198, Gif-sur-Yvette, France Breathing in mammals starts in the foetus and acquires a vital importance at birth. The ability to produce rhythmic motor behav- iours linked to respiratory function is a property of the brainstem reticular formation, which has been remarkably conserved during the evolution of vertebrates. Therefore, to understand the biological basis of the breathing behavior, we are investigating conservative developmental mechanisms orchestrating the organogenesis of the brainstem. In vertebrates, the hindbrain is one of the vesicles that appears at the anterior end of the neural tube of the embryo. Further morphogenetic subdivision ensues whereby the hindbrain neuroepithelium becomes partitioned into an iterated series of compartments called rhombomeres. The segmentation process is believed to determine neuronal fates by encoding positional infor- mation along the rostro-caudal axis. Before and at the onset of seg- mentation, genes encoding transcription factors such as Hox, Krox-20, kreisler, are expressed in domains corresponding to the limits of future rhombomeres. Inactivation of these genes specifi- cally disturbs the rhombomeric pattern

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