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Permanent-use haemofilter based on porous glass capillaries

Authors
Journal
Journal of Membrane Science
0376-7388
Publisher
Elsevier
Publication Date
Volume
11
Issue
3
Identifiers
DOI: 10.1016/s0376-7388(00)81251-x
Disciplines
  • Biology

Abstract

Abstract Modules of surface-modified porous glass capillaries with a hydraulic conductivity of 0.25-0.70 ml min -1 mmHg -1 m -2 were tested for suitability for clinical haemofiltration by ex vivo dog experiments and by in vitro perfusion. The results show that (1) the construction of reusable haemofilters based on porous glass capillaries is possible; (2) operational data of testmodules are comparable with hollow-fiber high-flux haemofilters based on asymmetric cellulose acetate membranes; and (3) blood-surface interaction of porous glass capillaries is characterized by protein deposition which entails very low protein cutoff.

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