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Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation

Authors
Journal
Liver Transplantation
1527-6465
Publisher
Wiley Blackwell (John Wiley & Sons)
Volume
9
Issue
9
Identifiers
DOI: 10.1053/jlts.2003.50181
Disciplines
  • Medicine

Abstract

Abstract Neurotoxicity is a well-known side effect of tacrolimus-based immunosuppression after liver transplantation. Until now, only 31 cases of immunosuppression-associated leukoencephalopathy in liver transplant recipients reported in the literature are related to tacrolimus therapy. We report a patient who developed a posterior leukoencephalopathy syndrome, secondary to tacrolimus-based immunosuppression, after living donor liver transplantation. The special features of this case are the sudden and late onset of neurologic symptoms, a persistent comatose state, and increased signal intensity in follow-up MRI. (Liver Transpl 2003;9:983-985.)

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