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Atom transfer radical cyclizations mediated by the Grubbs ruthenium metathesis catalyst

Authors
Journal
Synlett
0936-5214
Publisher
Thieme Publishing Group
Publication Date
Keywords
  • Alkenes Role: Rct (Reactant)
  • Ract (Reactant Or Reagent) (Halo
  • Prepn
  • Of G-Lactones And G-Lactams Via Atom Transfer Radical Cyclizations Of Halo Alkenes Mediated By The G
  • Cyclization
  • Cyclization Catalysts (Prepn
  • Of G-Lactones And G-Lactams Via Atom Transfer Radical Cyclizations Of Halo Alkenes Mediated By The G
  • Lactones Role: Spn (Synthetic Preparation)
  • Prep (Preparation) (G-
  • Prepn
  • Of G-Lactones And G-Lactams Via Atom Transfer Radical Cyclizations Of Halo Alkenes Mediated By The G
  • Lactams Role: Spn (Synthetic Preparation)
  • Prep (Preparation) (G-Lactams
  • Prepn
  • Of G-Lactones And G-Lactams Via Atom Transfer Radical Cyclizations Of Halo Alkenes Mediated By The G

Abstract

The com. available ruthenium carbene complex RuCl2(:CHPh)(PCy3)2 efficiently catalyzes the cyclization of halo alkenes, e.g. Cl3CCO2CH2CH:CH2, to g-lactones and g-lactams, e.g. 3,3-dichloro-4-(chloromethyl)dihydro-2(3H)-furanone. [on SciFinder (R)]

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