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Genetic and physiological characterization ofEscherichia coliK12 mutants (tabC) which induce the abortive infection of bacteriophage T4

Authors
Journal
Virology
0042-6822
Publisher
Elsevier
Publication Date
Volume
87
Issue
2
Identifiers
DOI: 10.1016/0042-6822(78)90131-9

Abstract

Abstract A new type of Escherichia coli K12 mutant ( tabC) which induces the abortive infection of wild-type T4 bacteriophage has been isolated and characterized. The ( tabC) mutations mapped between ilvE and metE on the E. coli genetic map. The following conclusions were drawn from experiments in which ( tabC) host mutants were infected with wild-type T4: (i) DNA synthesis is delayed, (ii) both early and late RNAs are synthesized, (iii) ( tabC) gene product is indispensable throughout the period of infection, and (iv) neither normal head nor tail is produced, irrespective of a reduced but significant expression of the late genes. Two types of T4 compensator mutants ( comC-α and comC-β) which grow in tabC mutants have been isolated and mapped near gene 39 and in gene 45, respectively.

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