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Occurrence of cholesterol 7α- and 7β-hydroperoxides in rat skin as aging markers

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
178
Issue
1
Identifiers
DOI: 10.1016/0006-291x(91)91805-m

Abstract

Abstract Evidence for presence of cholesterol 7α- and 7β-hydroperoxides in rat skin was presented for the first time. The 7-hydroperoxides in rat skin were reduced with sodium borohydride and trimethylsilylated for identification with the authentic compounds by gas chromatography/mass spectrometry. A content of cholesterol 7-hydroperoxides in rat skin, determined by high performance liquid chromatography with a chemiluminescence detector, highly correlated with the age of rats ( r = 0.874; between 1 and 45 weeks old), indicating that cholesterol 7α- and 7β-hydroperoxides were good markers for aging.

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