Abstract 1. 1. Gastric secretion in White Leghorn cocks was studied following the intravenous administration of gastrin pentapeptide and histamine acid phosphate. 2. 2. Both hydrogen ion and pepsin secretion were inhibited by hexamethonium when gastrin pentapeptide was administered. Only hydrogen ion secretion was inhibited by hexamethonium when histamine and phosphate was administered. 3. 3. Gastric secretion stimulated by histamine acid phosphate was not inhibited by atropine administration. 4. 4. Gallus domesticus may be capable of a separation of acid and pepsin secretion from the same cell type. The intramural ganglia may play an important role in the control of gastric secretion in this species.