Affordable Access

Publisher Website

Heteronuclear NMR provides an accurate assessment of therapeutic insulin's quality

Authors
Journal
Journal of Pharmaceutical and Biomedical Analysis
0731-7085
Publisher
Elsevier
Publication Date
Identifiers
DOI: 10.1016/j.jpba.2013.02.016
Keywords
  • Sofast Nmr
  • Insulin
  • Lispro
  • Biodrug
  • Biosimilar
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Abstract New generations of drugs are using more and more often therapeutic proteins as the active ingredient, prompting the regulation agencies to adapt their analytical methods. Fast and unambiguous information on the secondary, tertiary and quaternary structure of the protein should be provided to assess the quality of these biodrugs. Recent developments of heteronuclear NMR methods, enabling their use on pharmaceutical formulated unlabeled proteins, provide an efficient way to perform such analysis, a feature that is illustrated here using various commercial formulations of insulins.

There are no comments yet on this publication. Be the first to share your thoughts.