Oral cancer has emerged as a significant cause of global public health concern in both developing and developed nations. Multiple socio-demographic and habit-related risk factors have been attributed to causing oral cancer. A diverse array of challenges exists in the global campaign to address the burden of oral cancer. Such challenges have served as barriers to the early diagnosis and treatment of oral cancer, thus impacting the scope of the public health benefit and chances for survival. Oral health screening services should be integrated into National Public Health Programs and the development of an evidence-base on strategies which focus on primary prevention and community health education will assist in efforts to detect and treat oral cancer at earlier stages in the epidemiology of the disease.ReferencesWorld Health Organization. Oral health - Fact sheet N°318, 2012. [http://www.who.int/mediacentre/factsheets/fs318/en/]Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009; 45(4-5): 309-16.Coelho KR. Challenges of the oral cancer burden in India. J Cancer Epidemiol 2012; 2012: 701932.Zohoori FV, Shah K, Mason J, Shucksmith J. Identifying factors to improve oral cancer screening uptake: a qualitative study. PLoS One 2012; 7(10): e47410.Lin WJ, Jiang RS, Wu SH, Chen FJ, Liu SA. Smoking, alcohol, and betel quid and oral cancer: a prospective cohort study. J Oncol 2011; 2011: 525976.Stanko P, Kruzliak P, Labas P. Role of human papilloma virus infection and oral-genital contact in oral cancer etiopathogenesis. Bratisl Lek Listy 2013; 114(6): 345-8.Pakfetrat A, Falaki F, Esmaily HO, Shabestari S. Oral cancer knowledge among patients referred to Mashhad dental school, Iran. Arch Iran Med 2010; 13(6): 543-8.Rahman B, Hawas N, Rahman MM, Rabah AF, Al Kawas S. Assessing dental students' knowledge of oral cancer in the United Arab Emirates. Int Dent J 2013; 63(2): 80-4.Saleh A, Yang YH, Wan Abd Ghani WM, Abdullah N, Doss JG, Navonil R, et al. Promoting oral cancer awareness and early detection using a mass media approach. Asian Pac J Cancer Prev 2012; 13(4): 1217-24. Kujan O, Sloan P. Dilemmas of oral cancer screening: an update. Asian Pac J Cancer Prev 2013; 14(5): 3369-73.