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Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates

Authors
Journal
BMC Neurology
1471-2377
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Issue
1
Identifiers
DOI: 10.1186/1471-2377-7-9
Keywords
  • Research Article
Disciplines
  • Design
  • Medicine

Abstract

1471-2377-7-9.fm ral ss BioMed CentBMC Neurology Open AcceResearch article Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates Barbara Borroni*1, Mario Grassi2, Chiara Agosti1, Barbara Paghera3, Antonella Alberici1, Monica Di Luca4, Daniela Perani5 and Alessandro Padovani1 Address: 1Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy, 2Department of Health Sciences, Section of Medical Statistics & Epidemiology, University of Pavia, Pavia, Italy, 3Nuclear Medicine, Brescia Hospital, Brescia, Italy, 4Centre of Excellence for Neurodegenerative Disorders and Department of Pharmacological Sciences, University of Milan, Milan, Italy and 5Vita Salute San Raffaele University and IRCCS H San Raffaele, IBFN-CNR, Milan, Italy Email: Barbara Borroni* - [email protected]; Mario Grassi - [email protected]; Chiara Agosti - [email protected]; Barbara Paghera - [email protected]; Antonella Alberici - [email protected]; Monica Di Luca - [email protected]; Daniela Perani - [email protected]; Alessandro Padovani - [email protected] * Corresponding author Abstract Background: Frontotemporal Lobar Degeneration (FTLD) thus recently renamed, refers to a spectrum of heterogeneous conditions. This same heterogeneity of presentation represents the major methodological limit for the correct evaluation of clinical designation and brain functional correlates. At present, no study has investigated clinical clusters due to specific cognitive and behavioural disturbances beyond current clinical criteria. The aim of this study was to identify clinical FTLD presentation, based on cognitive and behavioural profile, and to define their SPECT functional correlations. Methods: Ninety-seven FTLD patients entered the study. A clinical evaluation and standardised assessment were preformed, as well as a brain SPECT perfusion imaging study. Latent Pr

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