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Coagulant activity of the scorpion venomsPalamneus gravimanusandLeiurus quinquestriatus

Authors
Journal
Toxicon
0041-0101
Publisher
Elsevier
Publication Date
Volume
12
Issue
3
Identifiers
DOI: 10.1016/0041-0101(74)90072-5

Abstract

Abstract The in vitro effects of the venom of two scorpions ( Palamneus gravimanus and Leiurus quinquestriatus) upon the coagulation mechanism of man has been investigated. The crude venom of P. gravimanus has both procoagulant and anti-coagulant properties partially separable by DEAE-Sephadex column chromatography; the crude venom of L. quinquestriatus is anti-coagulant with minimal coagulant activity: neither venom has fibrinolytic activity. Further experiments with partially purified fractions of P. gravimanus venom suggest that the procoagulant activity promotes Factor X activation while the anticoagulant fraction interferes with the action of thrombin upon fibrinogen, in part by making fibrinogen less susceptible to the clot promoting activity of thrombin.

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