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Plaque-Phase Mycosis Fungoides Treated with Photodynamic Therapy: Results from 12 Patients

Authors
Journal
Actas Dermo-Sifiliográficas (English Edition)
1578-2190
Publisher
Elsevier
Publication Date
Volume
101
Issue
9
Identifiers
DOI: 10.1016/s1578-2190(10)70717-4
Keywords
  • Mycosis Fungoides
  • Photodynamic Therapy
  • Methyl Aminolevulinate
  • Micosis Fungoide
  • Terapia Fotodinámica
  • Metilaminolevulínico
Disciplines
  • Medicine

Abstract

Abstract Background Recent years have seen an increase in the off-label use of photodynamic therapy for the treatment of a variety of skin diseases. Plaque-phase mycosis fungoides is among the most promising possibilities for the use of this treatment. Objectives To evaluate the treatment of plaque-phase mycosis fungoides with photodynamic therapy and compare the results obtained using fluorescence photography. Material and methods We performed a prospective, descriptive, observational study. Twelve patients with 24 lesions were treated with topical methyl aminolevulinate (MAL) under an occlusive dressing for 3 hours, followed by 8 minutes of red light (630 nm, 37 J/ cm 2; Aktilite). Results Six patients had a complete response, 5 a partial response, and 1 did not respond to treatment. A mean of 5.7 sessions was applied and no side effects were reported. Treatment tolerance was excellent. Conclusions Photodynamic therapy with MAL appears to be a good treatment option for patients with plaque-phase mycosis fungoides with a small number of lesions.

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