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Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.

Authors
  • 1
Type
Published Article
Journal
BMC Cancer
1471-2407
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
8
Pages
133–133
Identifiers
DOI: 10.1186/1471-2407-8-133
PMID: 18474089
Source
Medline

Abstract

Although transcription is a fundamental process, targeting select core transcription factors may provide for a new and potent avenue for cancer therapeutics. In the present study, knockdown of TFIIS inhibited cancer cell proliferation, suggesting that TFIIS could be studied as a potential cancer target within the transcription machinery.

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