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REGULATION OF VITAMIN-D METABOLISM WITHOUT PARATHYROID HORMONE

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
302
Issue
7824
Identifiers
DOI: 10.1016/s0140-6736(73)90794-0
Disciplines
  • Medicine

Abstract

Abstract Thyroparathyroidectomised (T.P.T.X.) rats on a high-calcium diet were given a low-calcium, low-phosphate diet. There was a pronounced increase in production of 1,25-dihydroxycholecalciferol (1,25-D.H.C.C.), the active metabolite of vitamin D, which was not explained by a fall in plasma-phosphate. Thus, parathyroid hormone is not necessary for the initiation of increased production of 1,25-D.H.C.C. by the kidney, and is therefore not the trophic hormone for this renal endocrine system. A likely determinant of the type of vitamin-D metabolite produced is the intracellular calcium concentration within some critical compartment of the renal cell.

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