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Additive models for dependent cell populations

Authors
Journal
Journal of Theoretical Biology
0022-5193
Publisher
Elsevier
Publication Date
Volume
109
Issue
1
Identifiers
DOI: 10.1016/s0022-5193(84)80115-0

Abstract

We propose an additive model for cell population growth which allows for positive correlation between sister cell lifetimes but arbitrary correlations between mother and daughter cell lifetimes. In the model each cell lifetime is the sum of two independent components, one of which is shared with its sister cell and which is also a function of the components of the lifetime of their mother. Assuming that the components follow a gamma distribution, the model is fitted to cell lifetime data of EMT6 cells obtained by the method of time-lapse cinematography.

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