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Absence of linkage between the interleukin-6 gene (−174 G/C) polymorphism and migraine

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
343
Issue
3
Identifiers
DOI: 10.1016/s0304-3940(03)00304-5
Keywords
  • Interleukin-6
  • Migraine
  • Aura
  • Tension-Type Headache
  • Anxiety
Disciplines
  • Biology
  • Medicine

Abstract

Abstract To assess the role of interleukin-6 (IL-6) in migraine, we analyzed the −174 G/C IL-6 gene polymorphism in 268 patients with migraine and 305 controls. No significant difference in the distribution of IL-6 genotypes ( χ 2=0.601, P=0.74) and allelic frequencies ( χ 2=0.024, P=0.876) was found. When patients were subdivided into subgroups (migraine with aura, migraine without aura and mixed headaches), IL-6 alleles were similarly distributed. Comparison of the clinical features of the disease with the −174 G/C IL-6 genotypes showed no significant difference. In conclusion, we found no significant association between the −174 G/C IL-6 polymorphism and the occurrence or the clinical features of migraine.

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