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Development of an electrochemical90Sr–90Y generator for separation of90Y suitable for targeted therapy

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
35
Issue
2
Identifiers
DOI: 10.1016/j.nucmedbio.2007.10.009
Keywords
  • 90Sr–90Y Generator
  • Electrochemical Separation
  • Radionuclidic Purity
  • 90Sr Contamination
  • Targeted Therapy
  • Kamadhenu
Disciplines
  • Chemistry
  • Medicine
  • Pharmacology
  • Religious Science

Abstract

Abstract 90Y of high specific activity and very high radionuclidic purity (>99.998%) is essential for targeted therapy. Since the current methods used for the preparation of 90Y from 90Sr are not adaptable for use in a central/hospital radiopharmacy, a simple 90Sr– 90Y generator system based on electrochemical separation technique was developed. Methods Two-cycle electrolysis procedure was developed for separation of 90Y from 90Sr in nitrate solution. The first electrolysis was performed for 90 min in 90Sr(NO 3) 2 feed solution at pH 2–3 at a potential of −2.5V with 100–200 mA current using platinum electrodes. The second electrolysis was performed for 45 min in 3 mM HNO 3 at a potential of −2.5V with 100 mA current. In this step, the cathode from the first electrolysis containing 90Y was used as anode along with a fresh circular platinum electrode as cathode. The 90Y deposited on the circular cathode after the second electrolysis was dissolved in acetate buffer to obtain 90Y acetate, suitable for radiolabeling. Results >96% recovery of 90Y could be achieved in each cycle, with an overall decay corrected yield of >90%. The recovered 90Y had high radionuclidic purity with barely 30.2±15.2 kBq (817±411 nCi) of 90Sr per 37 GBq (1 Ci) of 90Y (0.817±0.411 ppm). Consistent and repeated separation could be demonstrated using up to 1.85 GBq (50 mCi) of 90Sr. The generator was named “Kamadhenu,” the eternally milk-yielding Indian mythological cow. Conclusions A technique suitable for adaptation at central radiopharmacies for obtaining therapeutic quantities of pure 90Y has been developed.

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