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Granular-cell tumor of trachea masquerading as hurthle-cell neoplasm on fine-needle aspirate: A case report

Diagnostic Cytopathology
Wiley Blackwell (John Wiley & Sons)
Publication Date
  • Biology
  • Chemistry
  • Medicine


We report on a case of extraluminal tracheal granular-cell tumor which was interpreted as a Hurthle-cell neoplasm of the thyroid on fine-needle aspirate. Review of the literature reveals only one other such case. The patient was a 35-yr-old female who presented with an enlarged thyroid. Aspiration cytology revealed a syncytium of cells with abundant granular cytoplasm interpreted as a thyroid follicular neoplasm with Hurthle-cell change. However, histology of the resection specimen with immunohistochemistry confirmed it as a granular-cell tumor. The cytologic differential diagnosis of neoplasms with oncocytoid cytoplasm in and around the thyroid should include granular-cell tumor of the trachea. Diagn. Cytopathol. 22:379–382, 2000. © 2000 Wiley-Liss, Inc.

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