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Roles of A- and D-type K channels in EPSP integration at a model dendrite

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
254
Issue
3
Identifiers
DOI: 10.1016/s0304-3940(98)00679-x
Keywords
  • Dendritic Integration
  • K Channels
  • Computer Simulation
  • Cable Theory
Disciplines
  • Biology

Abstract

Abstract We examined the roles of A- and D-type K channels in the integration of EPSPs, particularly EPSP reduction, in a model dendrite using a computer simulation program (NEURON), instead of conventional electrophysiological methods which present technical difficulties. We obtained two important results: (1) KD channels play a crucial role in every synaptic input event, and (2) KA channels affect reduction of the second EPSP only when the second synaptic input is applied with a short interval (≤100 ms). These results suggest that KD channels, which have not yet been analyzed experimentally, play a major role in synaptic integration in dendrites by altering their cable properties.

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