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N-acyl-3-alkylidenyl- and 3-alkyl azeitidin-2-ones: a new class of monocyclic β-lactam antibacterial agents 2. Synthesis and structure-activity relationships of heteroatom substituted 3-isopropylidene and 3-isopropyl analogs

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
3
Issue
11
Identifiers
DOI: 10.1016/s0960-894x(01)80932-x

Abstract

Abstract O-, N-, or F-substituted 3-isopropylidene- and 3-isopropyl N-acyl azetidin-2-ones, lacking an ionizable moiety attached to the lactam nitrogen, have in vitro antibacterial activity, being particularly potent vs anaerobes.

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