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Structural and functional diversity of viral IRESes

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
1874-9399
Publisher
Elsevier
Publication Date
Volume
1789
Identifiers
DOI: 10.1016/j.bbagrm.2009.07.005
Keywords
  • Virus
  • Picornavirus
  • Ires
  • Eif4G
  • Translation Initiation
  • Eif
  • Hiv
  • Retrovirus
  • Flavivirus
Disciplines
  • Biology

Abstract

Abstract Some 20 years ago, the study of picornaviral RNA translation led to the characterization of an alternative mechanism of initiation by direct ribosome binding to the 5′ UTR. By using a bicistronic vector, it was shown that the 5′ UTR of the poliovirus (PV) or the Encephalomyelitis virus (EMCV) had the ability to bind the 43S preinitiation complex in a 5′ and cap-independent manner. This is rendered possible by an RNA domain called IRES for Internal Ribosome Entry Site which enables efficient translation of an mRNA lacking a 5′ cap structure. IRES elements have now been found in many different viral families where they often confer a selective advantage to allow ribosome recruitment under conditions where cap-dependent protein synthesis is severely repressed. In this review, we compare and contrast the structure and function of IRESes that are found within 4 distinct family of RNA positive stranded viruses which are the (i) Picornaviruses; (ii) Flaviviruses; (iii) Dicistroviruses; and (iv) Lentiviruses.

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