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Antibody-mediated regio- and enantioselective resolution of a glycerol derivative

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
7
Issue
2
Identifiers
DOI: 10.1016/s0960-894x(96)00612-9

Abstract

Abstract The antibody-mediated regio- and enantioselective hydrolysis of a glycerol derivative is reported. ( R)-2-Acetoxy-1-(3-nitrobenzyloxy)glycerol (80% ee) was obtained from the ( R, S)-2,3-diacetoxy glycerol derivative in 36% yield at the antibody-catalyzed kinetic resolution step.

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