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Relating thalamic neuronal activity and EMG for validating predictive control of deep-brain stimulation in Essential Tremor patients

Authors
Journal
BMC Neuroscience
1471-2202
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
12
Identifiers
DOI: 10.1186/1471-2202-12-s1-p129
Keywords
  • Poster Presentation
Disciplines
  • Medicine

Abstract

Relating thalamic neuronal activity and EMG for validating predictive control of deep-brain stimulation in Essential Tremor patients POSTER PRESENTATION Open Access Relating thalamic neuronal activity and EMG for validating predictive control of deep-brain stimulation in Essential Tremor patients Daniel Graupe1,2*, Ishita Basu1, Daniela Tuninetti1, Konstantin V Slavin3 From Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011 Neuronal activity at the VIM nucleus of the thalamus was recorded in Essential Tremor (ET) patients during implantation of deep-brain stimulation (DBS) electrodes and compared with surface-EMG (sEMG) taken both during implantation and at later outpatient sessions at University of Illinois Hospital, Chicago. The goal of these studies was to investigate if it is possible to use sEMG signals for predicting onset of tremor and conse- quently whether predictive EMG-control of DBS in ET patients does or does not contradict predictive features of neuronal activity in the brain. For this purpose, we examined spike-rate and local field potentials (LFP) at and in the vicinity of VIM. Specifically, we compared spike-rate, LFP and sEMG recorded before versus after applying short DBS pulse-trains during implantation surgery, as well as sEMG recorded from limbs or neck of the patients. Out of 4 ET patients involved in the tests, we have implant-session data for 3 patients. Three patients had follow-up EMG testing. Results Results show that spike rate dropped from 15.94 spikes/ s to 0.97 at the end of a DBS pulse-train in patient ET1, from 45.44 to 34.78 in patient ET3 and from 22.9 to 0.26 in Patient ET 4, for periods on 12-40 seconds (Fig 1-left). LFP power dropped in one of the 2 patients where it was measured. EMG recordings are presented in [1], yielding parameters that allow prediction of onset of tremor in every cycle of DBS-on/off, noting the delayed onset of tremor. Similar results were obtained in 2 of the remaining

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