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Highly diastereoslective synthesis of di- and trisubstituted 4-butanolides from aldehydes and ketones via three-carbon-extension by allylic homoenolate reagents

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
24
Issue
16
Identifiers
DOI: 10.1016/s0040-4039(00)81745-1

Abstract

Abstract Lithiated or titanated O -allyl carbamates 7 or 8 add to aldehydes and ketones regio- and diastereoselectively to yield O -(4-hydroxy-1-alkenyl) carbamates 9, which are converted to λ-lactones 12 with an one-pot procedure.

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