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Early impairment of synaptic plasticity in patients with Down's syndrome

Authors
Journal
Neurobiology of Aging
0197-4580
Publisher
Elsevier
Publication Date
Volume
29
Issue
8
Identifiers
DOI: 10.1016/j.neurobiolaging.2007.02.025
Keywords
  • Transcranial Magnetic Stimulation
  • Ltp
  • Down'S Syndrome

Abstract

Abstract We investigated synaptic plasticity in persons with Down’ syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.

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