Affordable Access

Publisher Website

Zinc triflate-catalyzed synthesis of pyrazino[2,1-b]quinazoline-3,6-diones

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
64
Issue
40
Identifiers
DOI: 10.1016/j.tet.2008.07.071
Keywords
  • Zinc Triflate
  • Cyclodehydration
  • Anthranilic Acid
  • Peptide
  • Pyrazino[2
  • 1-B]Quinazoline-3
  • 6-Dione

Abstract

Abstract Using zinc triflate, the direct one-pot double cyclodehydration of linear tripeptides to the total synthesis of pyrazino[2,1- b]quinazoline-3,6-diones ( 1a– l) on solid support was achieved with good overall yields in short reaction time. These syntheses of the pyrazino[2,1- b]quinazoline-3,6-diones were conveniently achieved in only three steps, starting from the amino acid-bound Wang resin.

There are no comments yet on this publication. Be the first to share your thoughts.