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50 years of allosteric interactions: the twists and turns of the models.

Authors
  • Changeux, Jean-Pierre
Type
Published Article
Journal
Nature Reviews Molecular Cell Biology
Publisher
Springer Nature
Publication Date
Dec 01, 2013
Volume
14
Issue
12
Pages
819–829
Identifiers
DOI: 10.1038/nrm3695
PMID: 24150612
Source
Medline
License
Unknown

Abstract

The concept of indirect or 'allosteric' interaction between topographically distinct sites, and the subsequent 1965 Monod-Wyman-Changeux (MWC) model for the conformational change mediating them, arose around 50 years ago. Many classic regulatory proteins (including haemoglobin, Asp transcarbamylase and nicotinic acetylcholine receptor) follow the central paradigm of the MWC model, which has been expanded and challenged as a result of novel technologies. Importantly, the concept of allosteric interaction has aided our understanding of human diseases and drug design.

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