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5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids.

Authors
  • Parker, R A
  • Kariya, T
  • Grisar, J M
  • Petrow, V
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
Jun 01, 1977
Volume
20
Issue
6
Pages
781–791
Identifiers
PMID: 406395
Source
Medline
License
Unknown

Abstract

5-(Tetradecyloxy)-2-furancarboxylic acid (91, RMI 14514) was found to lower blood lipids and to inhibit fatty acid synthesis with minimal effects on liver weight and liver fat content. This fatty acid-like compound represents a new class of hypolipidemic agent; it is effective in rats and monkeys. The compound resulted from discovery of hypolipidemic activity in certain beta-keto esters, postulation and confirmation of the corresponding benzoic acids as active metabolites, and systematic exploration of the structure--activity relationships.

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