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5-methyl-dCTP deaminase induced by bacteriophage XP-12.

Authors
Type
Published Article
Journal
Journal of virology
Publication Date
Volume
42
Issue
1
Pages
42–48
Identifiers
PMID: 7086962
Source
Medline
License
Unknown

Abstract

Bacteriophage XP-12, whose DNA contains 34 mol% 5-methylcytosine, induces the synthesis of a unique enzyme, 5-methyl-dCTP deaminase. The substrate for this enzyme, 5-methyl-dCTP, is produced by reactions catalyzed in part by other phage-induced enzymes, and the product of the reaction is dTTP. The deaminase therefore provides a novel pathway for biosynthesis of thymine residues for phage XP-12 DNA. Evidence is presented that this pathway is used for dTTP synthesis in XP-12-infected Xanthomonas oryzae.

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