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5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo.

Authors
  • Buchheit, K H
  • Costall, B
  • Engel, G
  • Gunning, S J
  • Naylor, R J
  • Richardson, B P
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Sep 01, 1985
Volume
37
Issue
9
Pages
664–667
Identifiers
PMID: 2867192
Source
Medline
License
Unknown

Abstract

Contractions induced by electrical field stimulation of isolated circular muscle strips, taken from the guinea-pig stomach, were enhanced by metoclopramide, ICS 205-930 and MDL 72222 at concentrations similar to those shown to antagonize at neuronal 5-hydroxytryptamine receptor sites in a variety of preparations. Metoclopramide, MDL 72222 and ICS 205-930 also facilitated gastric emptying in-vivo. The abilities of metoclopramide, MDL 72222 and ICS 205-930 to enhance stomach muscle contraction processes and to facilitate gastric emptying may be the consequence of 5-hydroxytryptamine receptor antagonism.

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