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5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.

Authors
Type
Published Article
Journal
Organic & Biomolecular Chemistry
1477-0520
Publisher
The Royal Society of Chemistry
Publication Date
Volume
4
Issue
6
Pages
1091–1096
Identifiers
PMID: 16525553
Source
Medline

Abstract

Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.

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