Affordable Access

5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.

Authors
  • Skorobogatyi, Mikhail V
  • Ustinov, Alexei V
  • Stepanova, Irina A
  • Pchelintseva, Anna A
  • Petrunina, Anna L
  • Andronova, Valeriya L
  • Galegov, Georgi A
  • Malakhov, Andrei D
  • Korshun, Vladimir A
Type
Published Article
Journal
Organic & biomolecular chemistry
Publication Date
Mar 21, 2006
Volume
4
Issue
6
Pages
1091–1096
Identifiers
PMID: 16525553
Source
Medline
License
Unknown

Abstract

Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.

Report this publication

Statistics

Seen <100 times