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5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.

Authors
  • Auberson, Y P
  • Acklin, P
  • Allgeier, H
  • Biollaz, M
  • Bischoff, S
  • Ofner, S
  • Veenstra, S J
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 06, 1998
Volume
8
Issue
1
Pages
71–74
Identifiers
PMID: 9871631
Source
Medline
License
Unknown

Abstract

Potent antagonists at the glycine-binding site of NMDA receptors, as well as dual antagonists acting also at AMPA receptors have been identified in a series of 5-arylaminomethylquinoxaline-2,3-diones. A study of the structure-activity relationship of these compounds is reported here.

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