5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.

Y P Auberson; P Acklin; H Allgeier; M Biollaz; S Bischoff; S Ofner; S J Veenstra

5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.

Authors

Auberson, Y P
Acklin, P
Allgeier, H
Biollaz, M
Bischoff, S
Ofner, S
Veenstra, S J

Type

Published Article

Journal

Bioorganic & Medicinal Chemistry Letters

Publisher

Elsevier

Publication Date

Jan 06, 1998

Volume

8

Issue

1

Pages

71–74

Identifiers

PMID: 9871631

Source

Medline

License

Unknown

Abstract

Potent antagonists at the glycine-binding site of NMDA receptors, as well as dual antagonists acting also at AMPA receptors have been identified in a series of 5-arylaminomethylquinoxaline-2,3-diones. A study of the structure-activity relationship of these compounds is reported here.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/02/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/9871631

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