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Cyclodextrin based polymeric particles with controlled disruption properties

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  • Medicine


Cyclodextrin based polymeric particles with controlled disruption properties Cyclodextrin based polymeric particles with controlled disruption properties Anne L. Nielsen1, Kim Steffensen2, and Kim L. Larsen1 1Section of Chemistry, Department of Biotechnology and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, DK-9000 Aalborg; 2Cheminova A/S, Thyborønvej 78, DK-7673 [email protected] ABSTRACT SUMMARY Here we present the formation of particles with controlled disruption abilities for controlled drug delivery purposes. They are made by self-assembly of cyclodextrin (CD) polymers and hydrophobically modified dextran. This is followed by a controlled disruption of the particles by addition of a trigger molecule competing for the CD cavities. INTRODUCTION The targeted delivery of drugs to a specific place or tissue in the human body offers numerous challenges for scientists today. Controlled delivery of powerful drugs such as chemotherapeutic agents affecting only the target tissue, leaving the healthy tissue untreated is of great interest. Several approaches have been addressed for this purpose, such as enviro-sensitive particles in the form of hydrogels [1] or encapsulation of the drug in phospholipids [2]. Particles capable of responding to external stimuli can offer the advantage of the drug being released exactly where and when it is needed. Cyclodextrins (CD) have the ability to form inclusion complexes with a wide range of molecules. In this study polymers with CDs as pendants were made from CD derivatives and were highly water-soluble. A complementary polymer strand was made of hydrophobic modified dextrans, carrying benzoate moieties. Thereby both of the two polymer types in the formed particles are biocompatible. EXPERIMENTAL METHODS PVP-co-β-CD-NMA (pCD) was synthesized by free- radical polymerization from reactive CD-n- methylolacrylamide (CD-NMA) and vinylpyrrolidone (VP) in aqueous solution using azobisis

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