Abstract The literature on idiopathic juvenile hypoparathyroidism and superficial moniliasis has been reviewed, and a case has been reported. This case involved a 13-year-old girl and was complicated by acid-fast achlorhydria. Thyroid, adrenal, and ovarian gland functions were analyzed for specific antibodies along with antinuclear factor, antigastric parietal cell, antimitochondrial, antirenal glomerular, and antismooth muscle antibodies. In some cases of this syndrome, the basic etiologic factor may be a parathyroid and thymus deficiency caused by a defect of branchial arch development. Because of the isolation of tissue-specific autoantibodies along with the systemic manifestations, it is more probable that an autoallergic process would help to explain the etiology of this syndrome. Circulating precipitin antibodies to Candida albicans may be significantly related to this process.