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Involvement of fast synaptic inhibition in the generation of high-frequency oscillation in central respiratory system

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
485
Issue
1
Identifiers
DOI: 10.1016/0006-8993(89)90684-7
Keywords
  • Phrenic Activity
  • Respiratory Rhythm
  • Oscillation
  • Spectral Analysis
  • Inhibitory Amino Acid Neurotransmitter
  • Strychnine
  • Bicuculline

Abstract

Abstract During moderate hypercapnia, spectrum analysis of efferent phrenic nerve activity (PNA) of urethane anesthetized rabbits revealed high-frequency oscillations (HFO). The spectral peak (mean frequency 111 Hz) was reversibly eliminated by the glycine receptor antagonist strychnine administered into the 4th cerebral ventricle. In contrast, blockade of brainstem GABA A receptors by bicuculline did not abolish HFO but even reinforced or induced HFO. Thus, there is evidence that fast synaptic inhibition via glycine receptors is involved in the generation of HFO within the medullary respiratory center, whereas GABA may play a modulatory role.

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