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An improved method to correct the QT interval of the electrocardiogram for changes in heart rate

Authors
Journal
Journal of Pharmacological Methods
0160-5402
Publisher
Elsevier
Publication Date
Volume
22
Issue
3
Identifiers
DOI: 10.1016/0160-5402(89)90015-6
Keywords
  • Electrocardiogram
  • Qt Interval
  • Heart Rate
  • Method
  • Anesthetized Dog

Abstract

Abstract The adequacy of the Bazett formula to correct for heart rate-induced changes in the QT interval of the electrocardiogram has been frequently questioned. In the present study, a simple linear equation was derived, which in anesthetized dogs corrects more adequately for changes in heart rate than the Bazett formula. Regression analysis of experimental data yielded the following equation: QT c = QT − 0.087 (RR − 1000) = QT − 87 ( 60 HR − 1) The reliability of this equation was investigated in experiments on anesthetized dogs with different cardioactive drugs with a known mechanism of action.

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